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Nanotechnology gives a range of options to lead to biology. Below I'll existing illustrations where by nanofabrication – a chance to make confined buildings with Proportions at will – is made use of to look at the biophysics of one molecules and cells. I'll existing some illustrations from our lab:

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, Groningen scientists existing the final results in their endeavours to make labs more sustainable and provide strategies for other labs. 

2007, first actual-time detection of strand Trade in homologous recombination by RecA; discovery of the minimal persistence duration of finishes of microtubules; and resolved the mechanism of biosensing with carbon nanotubes

2015, discovery that condensin is a remarkably versatile protein structure; and to start with detection of DNA knots working with nanopores

Instance (3) of bending configurations in 3D simulations of DNA rods on nanopores. A part of the membrane is proven in gray, the rim with the pore is highlighted https://www.ceesdekker.net in crimson, plus a 3D rendering in the movement with the DNA rod is displayed.

We condition micro organism into varieties that deviate from their normal phenotype. Exclusively, I will display our ability to condition Stay E. coli microorganisms into novel shapes such as rectangles, squares, triangles and circles.

Atomic pressure microscopy shows that vaccinia topoisomerase IB generates filaments on DNA inside a cooperative trend

In 1993, as a young and keen affiliate professor at Delft College of Engineering, I'd initially targeted the exploration endeavours of my group on measuring the electrical conductance of just one conducting-polymer molecule. Within just two years, we had developed a tool wherein just one wire of a phthalocyaninepolysiloxane polymer was linked between two closely spaced metal nanoelectrodes.

Resolving the stage size in condensin-driven DNA loop extrusion identifies ATP binding as the step-generating process

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2001, discovery of solitary-electron transistors at place temperature based upon nanotubes; realization of to start with logic circuits with carbon nanotube equipment; and discovery of the molecular composition of DNA repair enzymes with AFM

Allow’s very first seem back again at this time when you decided to shift your emphasis from superconductivity and nanotubes to biology at the conclusion of the nineties.

Supercoiling-dependent DNA binding: quantitative modeling and applications to bulk and one-molecule experiments