Examine This Report on cees dekker

‘Certainly, which is about suitable. I look for a Bodily idea of biological techniques in a very bottom-up way. I feel you could potentially distinguish three traces of exploration in my team in the intervening time. The first considerations chromosome framework: How does one obtain a metre-prolonged DNA polymer folded and organised in this kind of microscopic mobile? We have produced visualisation approaches that permit us to review how, such as, SMC proteins loop DNA (video on Youtube) to be able to Construct up chromosomes.

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‘It had been basically a make a difference of picking up a book on mobile biology and starting to read. I'd come from a world of extremely-large vacuums, cryostats and quantum phenomena, and now I was Performing at area temperature with molecular biology kits.

I can hardly visualize how I, to be a geneticist, would be able to learn essential physics, not to mention compete at the top. How did you go over it?

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In the a long time pursuing these discoveries, my research interests shifted to biophysics and nanobiology, and I grew to become a lot less involved in the development of nanotube electronics. The focus of many researchers in the sector also shifted to graphene (wherever, funnily enough, the very first graphene ribbons have been referred to as ‘nanotubes that happen to be cut open along their length’) soon after the invention of the two-dimensional content in 2004.

We use nanofabricated microfluidic constructions to sample spatial boundaries for germs and biomimetic vesicles with reconstituted protein networks which evaluate the fundamental job of spatial confinement at the molecular and cellular level. Our tasks contain the next:

Atomic power microscopy reveals that vaccinia topoisomerase IB generates filaments on DNA in the cooperative fashion

‘You shouldn't just take into consideration the questions of tomorrow, and also think about the thoughts in the working day following tomorrow’

Resolving the phase size in condensin-driven DNA loop extrusion identifies ATP binding as the action-generating course of action

An integrated microfluidic platform for quantifying drug permeation throughout biomimetic vesicle membranes

1999, 1st measurement with the wavefunction of one molecular orbitals of carbon nanotubes; and discovery of kink heterojunctions of carbon nanotubes which gave decisive proof for just a new Luttinger description of interacting electrons in nanotubes

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Supercoiling-dependent DNA binding: quantitative modeling and applications to bulk and solitary-molecule experiments